May function as a chaperone that inhibits aggregation of misfolded proteins . Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling . May also regulate the UPR via the EIF2AK3 UPR sensor . Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin .
Endoplasmic reticulum lumen . Cell membrane . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545). .
Expressed in platelets (at protein level).
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