Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex . Slows down the rate of inactivation of KCNC3 channels . Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools.
Mitochondrion . Endoplasmic reticulum . Nucleus membrane . Cytoplasmic vesicle . Cytoplasm, cell cortex . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Sarcoplasmic reticulum . Cytoplasm, P-body .; [Isoform 1]: Cytoplasm . Nucleus . Predominantly cytoplasmic. Also detected in the nucleus when nuclear export is inhibited, and in response to cellular stress caused by arsenite (in vitro). .; [Isoform 3]: Cytoplasm . Nucleus . Predominantly cytoplasmic. Also detected in the nucleus when nuclear export is inhibited (in vitro). .; [Isoform 4]: Cytoplasm . Nucleus . Shuttles between nucleus and cytoplasm. .; [Isoform 5]: Cytoplasm . Predominantly cytoplasmic. .
Ubiquitous. Up-regulated in oral cancers.
下载说明书
