Reversibly inhibits the activity of ATP2A1 and ATP2A2 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle. Required for muscle-based, non-shivering thermogenesis (By similarity).
Sarcoplasmic reticulum membrane ; Single-pass membrane protein . Endoplasmic reticulum membrane ; Single-pass membrane protein .
下载说明书
