Urate transporter, which may play a role in the urate reabsorption by proximal tubules . Does not transport glucose, fructose or galactose .
[Isoform 1]: Basolateral cell membrane ; Multi-pass membrane protein .; [Isoform 2]: Apical cell membrane ; Multi-pass membrane protein. Basolateral cell membrane ; Multi-pass membrane protein .
Most strongly expressed in basolateral membranes of proximal renal tubular cells, liver and placenta. Also detected in lung, blood leukocytes, heart skeletal muscle and chondrocytes from articular cartilage. Isoform 2 is only detected in the apical membranes of polarized renal tubular cells and placenta. Isoform 1 and isoform 2 are detected in kidney membrane (at protein level).
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