Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) . The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
Cytoplasm . Cytoplasmic vesicle, COPII-coated vesicle membrane ; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane ; Peripheral membrane protein . Cytoplasm, cytosol . Associates with membranes in a GTP-dependent manner (By similarity). Localizes to endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER) (PubMed:25201882, PubMed:28442536, PubMed:17428803). .
Abundantly and ubiquitously expressed.
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