Catalyzes the NAD(P)(+)-dependent oxidative decarboxylation of the C4 methyl groups of 4-alpha-carboxysterols in post-squalene cholesterol biosynthesis (By similarity). Plays also a role in the regulation of the endocytic trafficking of EGFR (By similarity).
Endoplasmic reticulum membrane ; Single-pass membrane protein . Lipid droplet . Trafficking through the Golgi is necessary for ER membrane localization. .
Brain, heart, liver, lung, kidney, skin and placenta.
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