Required for mitotic centrosome maturation and bipolar spindle assembly . Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication . Centrosome-specific activating scaffold for AURKA and PLK1 .
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Pericentriolar location in mitotic centrosomes.
下载说明书
