Functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex. May function in neuronal cells differentiation. May play a role in vesicular transport from endoplasmic reticulum to Golgi.
Golgi apparatus, cis-Golgi network . Endoplasmic reticulum . Cytoplasm . Processes and cell bodies of neurons. .
Expressed at high levels in muscle and kidney and to a lower extent in brain, heart and placenta.
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