Hydrolyzes a wide range of dipeptides including the conversion of leukotriene D4 to leukotriene E4 . Hydrolyzes cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (By similarity). Possesses also beta lactamase activity and hydrolytically inactivates beta-lactam antibiotics . ; Independently of its dipeptidase activity, acts as an adhesion receptor for neutrophil recruitment from bloodstream into inflamed lungs and liver.
Apical cell membrane ; Lipid-anchor, GPI-anchor . Cell projection, microvillus membrane ; Lipid-anchor, GPI-anchor . Brush border membrane. .
Expressed in lung and kidneys.
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