Acts as transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation . In presence of estrogen, binds to ESR1-responsive promoters . Required for YAP1 coactivation function on PGR activity . Synergizes with WBP2 in enhancing PGR activity . Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR (By similarity).
Cytoplasm . Nucleus . Translocates from cytoplasm to nucleus when phosphorylated. .
Ubiquitous.
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