Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway . In the presence of ABCE1 and PELO, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes . Together with PELO and in presence of ABCE1, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway . ; [Isoform 2]: Facilitates the association of the exosome complex with the SKI complex.
[Isoform 2]: Cytoplasm .
Detected in heart, brain, placenta, liver, muscle, kidney and pancreas.
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