Glycine receptors are ligand-gated chloride channels . Channel opening is triggered by extracellular glycine . Channel opening is also triggered by taurine and beta-alanine . Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization . Plays an important role in the down-regulation of neuronal excitability . Contributes to the generation of inhibitory postsynaptic currents . Channel activity is potentiated by ethanol . Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol (By similarity).
Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cell junction, synapse . Perikaryon . Cell projection, dendrite . Cell membrane ; Multi-pass membrane protein .
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