Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.
Cytoplasm . Cytoplasm, cytosol .
Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral blood.
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