Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form . It is involved in the negative regulation of the angiotensin-activated signaling pathway . Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein .
[Isoform 1]: Cell membrane . Cytoplasm . Nucleus, nucleolus .; [Isoform 2]: Cell membrane . Cytoplasm . Nucleus, nucleolus .; [Isoform 3]: Cell membrane . Cytoplasm . Nucleus, nucleolus .; [Isoform 4]: Cell membrane . Mitochondrion .
Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL).
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