Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.
[Isoform Alpha]: Lateral cell membrane; Lipid-anchor. Targeted predominantly to the lateral membrane.; [Isoform Beta]: Apical cell membrane; Lipid-anchor. Targeted predominantly to the apical membrane.
Expressed in brain, heart, lung, pancreas and skeletal muscle.
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