Plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome . Plays a role in lipid droplet formation . Induces lipid droplet clustering . Recruits ubiquitin-conjugating enzyme UBE2G2 to lipid droplets which facilitates its interaction with ubiquitin ligases AMFR/gp78 and RNF139/TRC8, leading to sterol-induced ubiquitination of HMGCR and its subsequent proteasomal degradation . Also required for the degradation of INSIG1, SREBF1 and SREBF2 . Plays a role in regulating assembly and secretion of very low density lipoprotein particles and stability of apolipoprotein APOB . ; (Microbial infection) Following Dengue virus infection, required for induction of lipophagy which facilitates production of virus progeny particles.
Endoplasmic reticulum membrane ; Peripheral membrane protein . Lipid droplet .; Cytoplasmic vesicle, autophagosome . (Microbial infection) Upon Dengue virus infection, relocates from lipid droplets to autophagosomes. .
Detected in blood platelets and leukocytes (at protein level). Ubiquitous. Highly expressed in placenta, liver, kidney, skeletal muscle, heart and brain.
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