Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER) . Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen . Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity).
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Widely expressed, with high levels in the liver.
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