Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing .
Nucleus . Cytoplasm . Nuclear location is required for recruitment of dynein motors to nuclear envelope at G2/M. .
Widely expressed. Tends to be up-regulated in seminomas compared to normal testis.
下载说明书
