Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway . Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors . Transports both D-serine and L-serine . Also able to transport other amino-acids, such as alanine . May be indirectly involved in the transport of a component required for iron utilization into or out of the mitochondria (By similarity).
Mitochondrion inner membrane ; Multi-pass membrane protein .
Highly expressed in tissues with high one-carbon metabolism activity, such as blood, liver and kidney.
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