Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity . Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation . May also promote acetylation of nucleosomal histone H4 by KAT5 . Promotes apoptosis . May act as a renal tumor suppressor . Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function .
Nucleus . Chromosome . Cytoplasm . Cytoplasm, cytoskeleton, cilium basal body . Localizes to the ciliary transition zone. .
Highly expressed in kidney. Also present in pancreas, liver and heart (at protein level). Down-regulated in renal cancer cells.
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