Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes . Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit . May play a role during development (By similarity).
Nucleus, nucleolus . Nucleus, nucleoplasm . Cytoplasm . Dynein axonemal particle . Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions. .
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