Has electrogenic activity in response to glucose, and may function as a glucose sensor . Mediates influx of sodium ions into the cell but does not transport sugars . Also potently activated by imino sugars such as deoxynojirimycin (DNJ) .
Cell membrane ; Multi-pass membrane protein .
Expressed in skeletal muscle, where it may localize to the neuromuscular junction (at protein level) (PubMed:13130073). Expressed in small intestine where it may localize to cholinergic neurons of the submucosal plexus and myenteric plexus (at protein level) (PubMed:13130073). Detected in kidney (at protein level) (PubMed:22766068).
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