Transcriptional regulator . Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters . Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated . As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 . May play a role in hematopoiesis . In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B .
Nucleus .
Ubiquitously expressed. Predominantly expressed in adult heart and testis and fetal lung and liver, with barely detectable expression in adult lung, liver, kidney, prostate, and peripheral leukocytes.
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