Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles . Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 . Can also catalyzes the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions .
Cytoplasm .
Expressed in a wide variety of tissues.
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