Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton . Promotes cytoplasmic microtubule nucleation and elongation . Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation . Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement . Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules . Acts as a regulator of autophagosome transport via interaction with CAMSAP2 . May play a role in cell migration (By similarity).
Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Golgi apparatus . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, spindle pole . Associated with the microtubule growing distal tips (PubMed:28814570). Recruitment to the Golgi apparatus requires the presence of PDE4DIP isoform 13/MMG8/SMYLE (PubMed:25217626). .
Ubiquitously expressed.
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