Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and enhances mRNA stability and gene expression . Can also elongate RNA oligos ending with uridine molecule, provided that the sequence is adenosine-rich . Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein . ; (Microbial infection) Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon.
Nucleus . Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Recruited into the centrosome through its interaction with PLK4. .
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