Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact.
Membrane; Peripheral membrane protein . Lateral cell membrane; Peripheral membrane protein . Cell junction, tight junction . Cell junction, adherens junction . Cytoplasm, cell cortex . Cytoplasm . In epidermal cells, detected primarily at the lateral cell membrane. .
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