May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape.
Cytoplasm . Cell membrane ; Lipid-anchor . Cytoplasmic vesicle, phagosome . Recruited to actin-rich phagosomes during phagocytosis. Translocates to the plasma membrane upon activation by RAC1 (By similarity). .; [Isoform 3]: Cytoplasm, cell cortex. Cell projection, bleb. Colocalized with F-actin in bleb protrusions.
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
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