Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels . Preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18 . May play an important physiological function in brain .
[Isoform 4]: Cytoplasm, cytosol .; [Isoform 6]: Cytoplasm, cytosol .; [Isoform 1]: Mitochondrion .; [Isoform 5]: Mitochondrion .
Isoform 4 is expressed exclusively in brain.
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