Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment . May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane (By similarity).
Photoreceptor outer segment membrane ; Single-pass type I membrane protein . Endoplasmic reticulum membrane ; Single-pass type I membrane protein .
Retina.
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