Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes . Can repress the expression of MMP7 in a ZBTB33-dependent manner . Can repress transactivation mediated by TCF12 . Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal .
Nucleus . Colocalizes with ATN1 in discrete nuclear dots.
Most abundantly expressed in brain. Lower levels in lung, heart, testis and ovary.
下载说明书
