FUSIP1 rabbit pAb

Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing . Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 . Required for splicing repression in M-phase cells and after heat shock . Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing . Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing . May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator .