Transcriptional repressor . Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3' . May act as a tumor suppressor . Involved in development of head, face, limbs and ventral body wall (By similarity). Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses . The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1 . In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells . Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes . Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex . Probably represses transcription of ACKR3, FGFBP1 and EFNA1 .
Nucleus .
Ubiquitously expressed with highest levels found in lung, colon, prostate, thymus, testis and ovary. Expression is absent or decreased in many tumor cells.
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