Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which is necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs) . May play a role in DNA damage response and may participate in cell proliferation and anchorage-independent cell growth .
Nucleus . Cytoplasm, cytoskeleton, spindle . Subcellular localization is independent of the interaction with cullins. .
Weakly expressed in testis, skin and immune tissues (thymus, spleen and lymph nodes).
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