Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate . Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration . Its GTP-sensing activity is critical for metabolic adaptation . PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 .
Endoplasmic reticulum membrane ; Peripheral membrane protein . Cell membrane ; Peripheral membrane protein . Nucleus . Cytoplasm . Associated with the plasma membrane and the endoplasmic reticulum. .
Highly expressed in brain, heart, pancreas, skeletal muscle and kidney. Detected at lower levels in placenta, lung and liver.
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