Required for pre-mRNA splicing as component of the spliceosome . Promotes exon-junction complex (EJC) assembly . Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay.
Nucleus . Nucleus speckle . Concentrates around speckles, which are sites of pre-mRNA synthesis and processing, where it colocalizes with EJC core proteins. .
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