Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 . Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity . Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7 .
Cell membrane ; Multi-pass membrane protein . Cell junction, adherens junction . Cytoplasm . Is localized to zonula adherens by PLEKHA7 by a PDZD11-dependent interaction. .
Predominantly expressed in erythroblasts.
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