Plays a positive role in the antiviral innate immune signaling pathway. Mechanistically, interacts with MAVS and functions as a positive regulator to promote 'Lys-63'-linked polyubiquitination of MAVS and thus strengthens the interaction between MAVS and TRAF2 . Plays also a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage (By similarity).
Cytoplasmic vesicle . Cell projection, axon . Cell projection, dendrite . In developing neurons, accumulates in early growth cones and at branching points of axons and dendrites. .
下载说明书
