Binds to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)) and phosphatidylinositol 4,5-bisphosphate. May be involved in several stages of intracellular trafficking.
Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side .
Highly expressed in fetus liver, but only weakly expressed in brain, skeleton muscle, smooth muscle, and cardiac muscle, kidney, and adrenal gland.
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