Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis.
Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Detected mainly at intracellular membranes upon overexpression in HeLa cells (PuMed:20147290), but not in other cell types.
Enriched in immune tissues, such as lymph nodes, B-lymphocytes, monocytes and spleen.
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