Catalyzes the transfer of phosphatidylinositol (PI) between membranes . Binds PI, phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC . Regulates RHOA activity, and plays a role in cytoskeleton remodeling . Necessary for normal completion of cytokinesis . Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus . Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus . Required for protein export from the endoplasmic reticulum and the Golgi . Binds calcium ions .
Cytoplasm. Golgi apparatus, Golgi stack membrane ; Peripheral membrane protein. Endoplasmic reticulum membrane ; Peripheral membrane protein. Lipid droplet . Cleavage furrow . Midbody . Peripheral membrane protein associated with Golgi stacks in interphase cells. A minor proportion is associated with the endoplasmic reticulum. Associated with lipid droplets (PubMed:12225667). Dissociates from the Golgi early on in mitosis and localizes to the cleavage furrow and midbody during cytokinesis (PubMed:15125835). .
Ubiquitous.
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