Acts as a dual histone chaperone and heat shock co-chaperone . As a histone chaperone, forms a co-chaperone complex with MCM2 and histone H3-H4 heterodimers; and may thereby assist MCM2 in histone H3-H4 heterodimer recognition and facilitate the assembly of histones into nucleosomes . May also act as a histone co-chaperone together with TONSL . May recruit histone chaperones ASF1A, NASP and SPT2 to histone H3-H4 heterodimers . Also plays a role as co-chaperone of the HSP70 family of molecular chaperone proteins, such as HSPA1A, HSPA1B and HSPA8 . As a co-chaperone, may play a role in the recruitment of HSP70-type molecular chaperone machinery to histone H3-H4 substrates, thereby maintaining the histone structural integrity . Exhibits activity to assemble histones onto DNA in vitro .
Nucleus . Cytoplasm . Cell membrane . Predominantly nuclear. Translocates to the cytoplasm and membrane after heat shock. .
Expressed in heart, placenta, liver, skeletal muscle, kidney, pancreas, thymus, ovary, colon and peripheral blood.
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