Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol . Plays a role in lipoprotein assembly and dietary cholesterol absorption . Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) and linolenoyl-CoA ((9Z,12Z,15Z)-octadecatrienoyl-CoA) as substrates . May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa . ; [Isoform 2]: Has lower enzymatic activity compared to isoform 1. ; [Isoform 3]: Has lower enzymatic activity compared to isoform 1.
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
Expression seems confined in hepatocytes and enterocytes.
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