[Fibrillin-2]: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. ; [Placensin]: Hormone secreted by trophoblasts that promotes trophoblast invasiveness . Has glucogenic activity: is able to increase plasma glucose levels (By similarity).
Secreted . Fibrillin-2 and Placensin chains are still linked together during the secretion from cells, but are subsequently separated by furin. .; [Fibrillin-2]: Secreted, extracellular space, extracellular matrix .; [Placensin]: Secreted . Secreted by placental cells. .
Almost exclusively expressed in placenta (PubMed:32329225). Expressed at much lower level in other tissues (PubMed:32329225). Expressed in fetal eye (18 weeks)in the retinal pigment epithelium (RPE), the choroid, Bruch's membrane and in the sclera (PubMed:24899048). Not expressed in the neural retina (PubMed:24899048). ; [Placensin]: Present at high level in cytotrophoblasts as compared with syncytiotrophoblasts at 8-9 weeks of pregnancy (at protein level) (PubMed:32329225). Levels in the serum increase during pregnancy (at protein level) (PubMed:32329225).
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