Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3.
Cytoplasm . Found in reticular structures and plasma membrane ruffles. Concentrated near the nucleus.
Expressed in various tissues, including heart, skeletal muscle, placenta, liver, lung, kidney and pancreas.
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