Component of a ribosome-associated endoplasmic reticulum (ER) translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis . May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NCLN/Nicalin (By similarity).
Endoplasmic reticulum membrane ; Single-pass membrane protein .
Expressed in colon tumor tissue and in adjacent normal colonic mucosa.
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