Acetyltransferase required for the establishment of sister chromatid cohesion . Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3 .
Nucleus . Chromosome . Nuclear in interphase cells, excluded from chromosomes during metaphase but reassociates with chromosomes in telophase. .
Widely expressed in fetal tissues. In adult, it is expressed in thymus, placenta and small intestine.
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