Involved in mitochondrial tRNA methylation . Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
Mitochondrion matrix . Nucleus . Cytoplasm . Predominantly in the mitochondria and in the nucleus. .
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