Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins . Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins . Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation .
Cytoplasm . Endoplasmic reticulum . Nucleus .
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