Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates . Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor . Also displays broad nucleoside diphosphate kinase activity . Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK . Plays a protective role in the cellular response to oxidative stress .
Mitochondrion matrix .
Highly expressed in kidney, moderately expressed in heart and liver and weakly expressed in brain.
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